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KMID : 0352119930090010024
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Journal of Kyung Hee University
1993 Volume.9 No. 1 p.24 ~ p.32
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The Effects of Intravenous Verapamil on Blood Pressure and Heart Rate During Endotracheal Intubation
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Kim Yong-Joo
Kim Keon-Sik
Kang Hwa-Ja
Choi Young-Kyu
Shin Ok-Young
Kwon Moo-Il
Shin Kwang-Il
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Abstract
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Many approaches have been tried to reduce the incidence and degree of hemodynamic changes during endotracheal intubation, but without satisfactory results. This study was undertaken to evaluate the effect of verapamil on the blood pressure and heart rate following endotracheal intubation. Forty, healthy, adult patients undergoing elective surgery under general anesthesia were selected and divided into two groups, the control and the experimental. 2 ml of saline was given intravenously to the control group and 0.1 mg/kg of verapamil, to the experimental group 75 seconds after induction of anesthesia. @ES The results are as following: @EN 1) With direct laryngoscopy, mean arterial pressure increased significantly during intubation (p<0.05) and returned to the preinduction level within 3 minutes in the control group.
No significant change was shown in the experimental group. Comparing the two groups, significant decreases in blood pressure were shown with direct laryngoscopy and 2 minutes after endotracheal intubation in the experimental group (p<0.05) and was no significant change 3 minutes after intubation. 2) Heart rate increased significantly from 1 minute to four minutes after induction in the control group (P<0.05). 3) Significant increase was shown in the experimental group, too, but showed significant decrease just after endotracheal intubation (p<0.05). It was decreased 1 minute after intubation as compared to the control group but not so significant. Based on the above results, it can be concluded that the intravenous injection of verapamil (0.1 mg/kg) is effective in reducing the hemodynamic changes during endotracheal intubation under general anesthesia.
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